De Montfort University PhD Scholarships

Please contact PGRscholarships@dmu.ac.uk if you have any questions.


De Montfort University is providing a number of fully-funded PhD scholarships offered within four clustered interdisciplinary research themes which students will reside within. The scholarships commence as of 1 October 2024. These exciting research themes will offer students: 

  • A stipend at UKRI rate (£19,237 per year)
  • Tuition fees
  • Access to an innovative Researcher Development Programme to further enhance your research and professional skills.

Research clusters

Each research cluster will provide students with innovative research expertise by academic staff within the detailed themes, providing professional development in academic and technical skills, aligned to an immersive student experience working with academic staff. The research clusters embed DMU’s research priorities aligned to the United Nations sustainability development goals. The four research clusters for students to consider are:

Design for Circularity

This research cluster intends to develop the technical research, industry strategy and design practice approach required for the circular economy in fashion, textiles and design. This proposal builds on excellent current and previous funded research, with the Innovate UK funded UK-Nigeria Circular Fashion Global Innovation Network; the AHRC-funded International Upcycling Research Network; the AHRC funded Making Historical Dress Network; and industry consultancy on textile recycling, enzyme-based biotechnology and sol-gel technology. It builds on the cluster’s international reputation and publication track record on sustainable textile innovation and biotechnology (from the TEAM research group); the circular economy; upcycling; sustainable/ slow fashion industry strategy; and historical dress construction analysis. It focuses on developing original processes and industry strategies for stages of the product lifecycle, including natural fibre innovation, sustainable supply chains, zero-waste pattern cutting, biodegradation of waste fabrics, upcycling waste wool and solar technology.

Please see projects below.

  1. Adapting Historical Zero Waste Cutting Methods for the Current Fashion Industry

    In late seventeenth-century Europe, mantua-makers revolutionised the way fashionable gowns were cut. Turning away from the complex shapes and tailoring methods required for earlier fashions, they instead adopted flat-cut and zero-waste approaches to cutting. Created through interlocking geometric shapes, and then draped on the body in intensely efficient ways, this style ensured that expensive textiles were used proficiently and economically.

    This PhD project explores how these historical zero-waste methods could be used to inform sustainable pattern cutting within the current fashion industry. Led through a practice-based intersection of recreative historical making practice and experimentation in design and cutting, this project will demonstrate the ways in which historical practices of garment manufacture could inform sustainable futures in the fashion industry.

    Potential applicants can contact Dr Serena Dyer, for any questions about the project or for informal enquiries.

  2. Developing a Nigerian Sustainable Fashion Supply Chain Strategy

    The PhD will examine the potential for establishing a sustainable supply chain for fashion SMEs in Nigeria. It will identify the barriers to a sustainable fashion industry and define sustainable development strategies. The research should consider the role of circular economy systems within the Nigerian fashion industry, with possible use of waste and recycled textiles. Analysis of the industry would be undertaken to examine localisation of production in materials to identify low carbon supply systems and to build on the strong cultural heritage of craft textiles produced in the area. Analysis of supply chain systems would be undertaken, to establish recommendations to improve access by fashion SMEs, transparency of material data and fair pay for the producers. This project would relate to the research by the UK-Nigeria Circular Fashion Network and wider research and developments by the African Circular Fashion Network and the Green Access programme by Lagos Fashion Week.

    Potential applicants can contact Dr Emily Baines, for any questions about the project or for informal enquiries.

  3. Design-led circular economy solutions for solar photovoltaic panels

    Renewable energy sources have the potential to fulfil global energy requirements without causing undue harm to the climate. Solar energy, specifically photovoltaics (PV), is one of the fastest expanding renewable energy sectors. While the environmental impact of PV panels is relatively small during operation, their production stage and end of life have significant negative environmental implications. The manufacturing of PV in the UK is comparatively small. Nevertheless, with the growing number of PV panel installations in the UK, significant waste is expected in the near future. This presents both a waste and pollution issue, as well as an opportunity for the circular economy. This project aims to explore promising circular economy solutions for PV panels, focusing on design-led solutions, such as creative and innovative reuse or repurposing of PV panels and components for financially viable new products and/or product service systems.

    Potential applicants can contact Dr Kyungeun Sung, for any questions about the project or for informal enquiries.

  4. Responsible Design: An investigation into Zandra Rhodes' Design Ethos and Working Practices

    This research explores the sustainability credentials of Zandra Rhodes' engineered designs, focusing on her pioneering use of zero waste principles. Through the use of 3D digital design, the study will consider how these techniques could enhance current sampling practice. Renowned for her vibrant prints and innovative textiles, this study makes use of Rhodes’ archive housed within the De Montfort University Special Collections. This collection offers a rich resource of business papers, design sketches, fabric samples, production notes, and finished garments to examine how fashion can integrate sustainable practices. This study will analyse her design processes, particularly her textile designs, strategic pattern cutting and fabric utilization, to identify methods that minimize waste in the sampling process. By documenting and evaluating her techniques, this research aims to establish a framework for sustainable digital fashion design practice. aligning with contemporary environmental imperatives.

    This project will employ archival research, design analysis, digital twin development and interviews with Rhodes and her contemporaries to construct a comprehensive understanding of her contributions to sustainable fashion. Ultimately, the research will contribute to academic discourse on sustainable design and offer practical insights for industry adoption, reinforcing the relevance of historical practices in addressing modern environmental challenges.

    Potential applicants can contact Professor Carolyn Hardaker, for any questions about the project or for informal enquiries.

  5. Textile biodegradation and end of life strategies for material sustainability

    This project focuses on the potential of biodegradation and compostability for the end-of-life management of a range of textiles, within the context of the biological cycle of the circular economy of textiles. With a raft of ongoing and upcoming regulatory and legislative powers disrupting the sector, the project will build on existing TEAM work liaising with the farming community and textile industry to create a viable solution to tackle waste.

    Exploratory work will allow the testing, benchmarking and experimental development of commonplace textile materials to be analysed to establish feasible solutions, methods and the infrastructure required for this solution to develop.

    The PhD will engage with existing farming, industry and government stakeholder contacts to develop a real world solution to textile waste. The outcomes of the PhD project could provide the knowledge and data for legislation, policy decision making and contribution to the preservation of the local environment.

    Potential applicants can contact Dr Angela Davies, for any questions about the project or for informal enquiries.

  6. Recycling and Reuse of Waste Wool: Enzymatic Extraction of Polypeptides and their Applications

    This project focuses on the enzymatic extraction of wool polypeptides from low value wool materials or waste wool fabrics and developing potential applications for different end uses.

    This work will extend and develop the previous innovative biotechnological research conducted by the supervisory team. Further development will be explored for regeneration of protein materials from the extracted wool polypeptides either in the forms of filaments or composite for biobased leather materials. The extracted polypeptides will also be applied back onto virgin wool fibres to achieve machine washable wool by developing innovative grafting technology including enzymatic crosslinking or sol-gel based surface polymer coating. The successful outcomes from the project will make contribution to the circular economy of wool manufacturing and production.

    The successful candidate will be supervised within the internationally-renowned TEAM (Textiles Engineering and Materials) Research Group, by Professor Jinsong Shen. Research work will be conducted in TEAM’s conditioned laboratory.

    Potential applicants can contact Professor Jinsong Shen, for any questions about the project or for informal enquiries.


Sustainable Economic Growth

The UK is the worst-performing economy in the G7 but with potential for rapid growth. Both the Chancellor and Shadow Chancellor have set out long term visions to grow the economy in a more spatially and socially balanced way.

Economic growth is a major research agenda internationally. It forms a central pillar for the next UK Government and though a national wealth fund, feeds into plans for combined regional authorities, national stakeholders and investor groups. Arising from underperforming economies and places, are extensive social problems and a patchwork of informal and improvised agency, under-researched as sustainable solutions. In this cluster, we bring these complex economic and social elements together to advance research on sustainable economic growth for economies, people, and places.

Please see projects below.

  1. Climate Change, Net-Zero Policies and Inclusive Economic Growth - Lessons from Countries with Large Informal Economy

    Developing countries are faced with both economic growth and climate change challenges. For example, estimates suggest that temperatures will rise by 2°C over the next 30 years. But according to the environmental Kuznet’s argument, a country’s path at the initial stages of growth is through industrialisation, which is expected to be accompanied by pollution. Thus, from economic theory, it may be difficult to pursue growth and net zero outcomes simultaneously. This is even more challenging in developing countries with large informal economies given that they mainly source their raw materials through unsustainable means and produce using outdated technologies and techniques. It thus raises an important question: in what ways and to what extent do climate change and net-zero policies hinder or promote inclusive economic growth? Our research will seek answers to this question. In addition, we will develop frameworks that will ensure an inclusive decarbonisation pathway for developing countries with large informal economy in their pursuit of net zero policies and economic growth.

    Potential applicants can contact Dr Eghosa Igudia, for any questions about the project or for informal enquiries.

  2. The impact of firm climate risk on capital allocation efficiency

    Efficient capital allocation directly enhances firms' profitability, growth, and competitiveness. It ensures that resources are allocated to high-return projects to maximize shareholder's wealth and financial stability. A significant challenge firms face today is the risks associated with climate change linked to carbon and greenhouse gas (GHG) emissions. However, other factors including environmental challenges may lead to the misallocation of firms' financial resources.

    The research will examine how firm climate risk affects capital allocation efficiency. The growing concern by the public and other stakeholders in the environment has served as motivation for policymakers to find ways to encourage firms to reduce emissions. We hypothesize that firm climate risk proxy by greenhouse carbon emissions will lead to inefficient capital allocation. This project includes the opportunity to work with large data set and develop quantitative research skills leading to publications in top-quality journals.

    Potential applicants can contact Dr Frank Kwabi, for any questions about the project or for informal enquiries.

  3. New Creative Economic Frameworks - Creative Anchors and Economic Capital

    The creative industries continue to play a significant role in the Midlands economy and yet over the last 25 years, research on the applied and normative aspects of creative economy models have been surprisingly scant. Functionally, the creative industries today are markedly different to the arts-based activities that emerged in the first few years of the new millennium. In collaboration with Leicester City Council and the Midlands Engine, we invite proposals that open up new and enriching research on the creative economy, with a particular focus on:

    1. The role of creative industries clusters, networks, and growth poles as drivers of regional economic performance with empirical application of the 4 and 6 models of the creative industries (Potts and Cunningham 2008, Granger 2024) and regional modelling (e.g. input-output analysis).
    2. The creative lifecycle and longitudinal economic frameworks that position an evolving creative economy as successive waves of capital investment and development of new ecosystems and maturing functions (e.g. the rise of civic creativity).
    3. The role of creative industries in knowledge exchange with a focus on spillovers, foreign direct investment, innovation precincts and districts, and within manufacturing and traditional sectors.
    4. Internationalisation of creative work with a particular focus on outsourcing, offshoring as international divisions of labour and vertical productions.
    5. Creative capital as new circuits of urban capital drawing (drawing on Lefebvre, 1970, and Harvey, 2010 revisiting the urbanisation of new capital)
    6. The economic impacts of creative job and place hopping

    Potential applicants can contact Professor Rachel Granger, for any questions about the project or for informal enquiries.

  4. Improving Environmental Performance of UK Food Logistics: The Case of Dairy and Meat Products

    UK dairy and meat products logistics and annual waste are main contributors to GHG emissions in the UK food supply chains. Among others, logistics management-related issues, such as poor demand forecasting, planning, and poor inventory management play a crucial role in exacerbating this adverse environmental impact of the food supply chains. However, as the UK aspires to reach net-zero GHG emissions by 2050, and now that Brexit has been completed, it is increasingly evident that new pragmatic approaches, policies, and system improvements are needed to abate GHG emissions in the UK food logistics. In the UK, dairy and meat products are, respectively, three- and 21-times emissions intensive than the average for fruits and vegetables, and consequently their GHG emissions becomes an important concern for public authorities and public body. This research aims at employing mathematical modelling techniques to investigate how environmental performance of UK dairy and meat products logistics in the UK can be improved to potentially contribute to reduced GHG emissions of UK food logistics.

    Potential applicants can contact Dr Ayham Jaaron, for any questions about the project or for informal enquiries.

  5. Supporting the Skills Economy and Alternative Spaces

    Skills and sustainable labour markets are intrinsic to structural transformation and sustainable economic growth. Whilst recent literature has been directed at employability, labour productivity and place-based models, as well as the aftermath of shocks such as the Global Financial Crisis and Covid-19, here, this PhD focuses on the unique problem created through the nexus of economic decline, austerity, and green transformations, and how we might overcome these complex problems to support sustainable economic growth through the skills economy. The rise of the skills economy is a response to the global skills shortage, where 87% of companies worldwide anticipate major skills gaps within the next 5 years. Of additional concern is how people from vulnerable, marginal or ‘excluded’ groups such as migrants and minorities are less able to participate in, and benefit from, entrepreneurship, fair employment and benefits of inclusive economic growth. This results in part from the spread of the informal economy and businesses operating on the margins of legality, for example in their compliance with employment, safety and other law and regulation.

    • Policy interventions to tackle historically high economic inactivity
    • Changing funding landscapes and the role of third-sector organisations (TSOs)
    • Alternative spaces within the informal economy, which represents 60% of the global workforce, and spaces for social justice
    • New research to open-up discussions on ‘decent work’, especially within new green economies
    • Financial literacy gaps, sustainability and economic growth, working to tackle the digital divide

    Potential applicants can contact Dr Alex Anlesinya, for any questions about the project or for informal enquiries.

  6. Overtaking barriers to growth: Creating accessible, sustainable and inclusive transport ecosystems

    The provision of safe, efficient and cost-effective public and active transport is a pre-requisite for the efficient functioning of place-based economies. Although much has been done to improve the accessibility of public transport for marginalised groups, transport spaces remain exclusionary and more work is required to make transport models truly accessible, sustainable and inclusive. At the same time, logistics, especially within the Midlands- context raises concerns about inclusive and welfare aspects of logistics work, and the green credentials of expanding air freight systems.

    Indicative research areas for this PhD:

    • Work on policy interventions to tackle place-based public transport use in different communities in Leicester
    • Inclusive supply chains that researches welfare concerns of logistics operations and workers as gig economies
    • The sustainability of air transportation through benchmarking approaches

    Potential applicants can contact Professor Lucy Budd, for any questions about the project or for informal enquiries.


Sustainable and Resilient Built Environment

The Sustainable and Resilient Built Environment (SuRe Buildings) cluster aims to create new knowledge for the advancement of resilient, eco-friendly, and comfortable buildings. By integrating cutting-edge research in thermal-comfort, visual-comfort, air-quality, occupant perception, nature-based solutions, passive house design, and clean energy integration, we strive to conduct ground-breaking research that would enhance the sustainability and liveability of buildings. Our interdisciplinary approach combines social and technical skills to address the unique challenges of the built environment in diverse contexts, both in the Global North as well as low-income communities of the Global South.

Through collaborative efforts with industry partners, policymakers, and local communities, we aim to generate impactful research that informs policy, drives technological innovation, and promotes sustainable practices. Ultimately, our ambition is to contribute to the creation of buildings that are not only energy-efficient and environmentally  sustainable but also conducive to the health, well-being, and satisfaction of all residents.

Please see projects below. 

  1. Evaluation of an innovative treatment technology for airborne PFAS pollution problem

    This project aims to advance knowledge in indoor air quality by developing and evaluating innovative treatment systems for persistent air contaminants, particularly Per- and poly-fluoroalkyl substances (PFAS), which pose significant health risks, especially in rapidly urbanizing areas of the developing world. Recognizing that indoor environments can often be more polluted than outdoor settings, this research focuses on enhancing indoor air quality through an energy-efficient, broad-spectrum treatment system for airborne PFAS, with a particular focus on applications in Asia. The project will establish the PFAS removal efficacy of the proposed system in laboratory settings, deploy the system in a portable standalone unit, and assess its effectiveness in real-world scenarios. By identifying limitations and exploring active interventions, this study aims to develop practical solutions to reduce PFAS exposure, improve indoor air quality, and promote healthier urban living environments.

    Potential applicants can contact Dr Abhishek Tiwary, for any questions about the project or for informal enquiries.

  2. Modelling Behaviour of residents for Clean Energy interventions in Low-Income Communities

    This project aims to understand and model the behaviour and preferences of African consumers in low-income communities regarding the adoption of low-carbon energy interventions. Using large-scale surveys (with help from project partners) and advanced behavioural theories such as choice experiments, structural equation modelling, the theory of planned behaviour, and the technology acceptance model, the research will identify factors influencing the adoption of renewable energy and energy efficiency measures. The insights will inform the design of tailored interventions that promote clean energy solutions, ensuring they are effective and culturally relevant. By leveraging networks and digital tools, the project will generate a novel dataset on consumer perceptions and preferences, ultimately contributing to improved energy access, sustainability, and economic development in low-income communities.

    Potential applicants can contact Dr Emmanouil Tyllianakis, for any questions about the project or for informal enquiries.

  3. Nature-based solutions and housing: identifying and scaling-up impactful approaches through policy, education and practice

    Housing provision in the UK and globally is experiencing a ‘poly-crisis’ shaped by demand pressures and the need to reduce carbon emissions, adapt to climate risks, use materials sustainably and to address social inequalities affecting quality, availability and affordability.

    Mainstream top-down development or retrofit approaches are not delivering sustainable development and frequently fail to respond to community needs identifiable through participatory design and management.

    In contrast, ‘Nature-based solutions’ is an internationally-recognised whole-systems framework for sustainable design, moving beyond a single-issue focus on in-use carbon emissions to innovatively address the circular economy, climate-change adaptation and more.

    This project would address the nexus of practice, policy and education, by working with built environment professionals, university educators and regional/national government in the UK and overseas to evaluate the viability of participatory nature-based solutions in range of contexts and how these can be scaled-up via policy, professional networks and innovation in taught course design.

    Potential applicants can contact Dr Andrew Reeves, for any questions about the project or for informal enquiries.

  4. Resilient Passivhaus design for social housing in a warming climate

    Passivhaus designs have been shown to reduce energy consumption and carbon emissions by 50% - 83% relative to conventional buildings, while enhancing the comfort of occupants. Unfortunately, there is growing concern about the risk of indoor overheating during summer, particularly in the UK, where climate change could exacerbate this issue. This challenge is especially acute in Passivhaus social housing projects, where the residents' limited financial means restrict their ability to adapt to and mitigate the impacts of potential extreme heat.

    This PhD will investigate optimal design and operation of Passivhaus project, using the 134-dwelling, £20M+ Hammersmith & Fulham council project(Figure 1) in collaboration with Calfordseaden, an award-winning multidisciplinary consultancy responsible for the project’s design and delivery.

    The primary research question is: How can optimal design and operation address the limitations of Passivhaus for social housing schemes in a warming climate?

    Potential applicants can contact Dr. Sanober Khattak, for any questions about the project or for informal enquiries.

  5. Advancing Thermal Comfort in Hot Climates

    This project, which build on DMU Research expertise, focuses on developing advanced thermal comfort models tailored to communities in hot climates, where existing Western standards often fail. E.g. Results from Thailand, India, Kenya, and Nigeria highlights the unique thermal comfort needs of these communities, indicating that current models significantly overestimate the operative temperatures, resulting in more energy consumption comfortable living conditions. The study will utilize Qualitative and quantitative data, adaptive approaches, numerical simulations, and cross-cultural research to assess thermal comfort levels in various architectural typologies. It will explore the impact of building design, outdoor elements such as living walls, occupant behaviour, and socio-cultural factors. By integrating data-driven models with qualitative insights into occupant preferences and behaviours, the project aims to develop optimal thermal comfort strategies. These strategies will enhance the well-being of residents by ensuring homes are built to maintain comfortable temperatures, reducing energy costs, and improving overall living conditions.

    Potential applicants can contact Prof. Ahmad Taki for any questions about the project or for informal enquiries.

  6. Enhancing Visual Comfort in Urban Buildings through Innovative Lighting Design

    This project aims to advance visual comfort by focusing on lighting design, occupant-centered approaches, and the impact of lighting on well-being and productivity. Given that individuals spend up to 90% of their time indoors, access to natural daylight and views through windows is crucial. The research will explore how window shade designs and lighting environments affect occupants' psycho-physiological responses, considering cultural and physiological differences. Using an experimental approach with semi-controlled conditions and virtual scenes, the study will collect and analyse data on occupant preferences and behaviour. It will also assess lighting quality in diverse settings and evaluate the effects of glare. The outcomes will develop frameworks to enhance building design, informing standards like the UK Lighting for Buildings 8206-2 and BREEAM. This research supports the UN Sustainable Development Goals,promoting health and well-being and sustainable urban living.

    Potential applicants can contact Dr. Sahar Abdelwahab Abdalrahman for any questions about the project or for informal enquiries.


Neuro-Resilience – Mechanisms of neurodegenerative disease and interventions supporting increased health-span and healthy brain ageing

This cluster comprises of a multidisciplinary, experientially and culturally diverse, and inclusive group of scientists who have been working collaboratively to unravel the intricate mechanisms by which the natural process of ageing contributes to the onset and progression of neurodegenerative diseases and mitigation strategies. The main framework for such collaborative research stems from the recognition that individual scientists' research themes possess significant overlap, collectively covering a diverse array of pathways through which negative life experiences and the process of natural ageing may induce cellular damage susceptible to triggering neurodegenerative conditions in later stages of life.

This is reflected in the diverse, yet overlapping research projects covered by the team investigating various factors that are implicated in neurobiology/neuropathology of the ageing brain, including exposure to chronic psychosocial stress and inflammation (MS), mitochondrial dysfunction (NM/MDP), lysosomal dysfunction (DS/SW), disruptions in the gut-brain axis (NM/MS), and circadian clock disturbances (CB). These will be complemented in the cluster by the addition of expertise in microbiology (LS & RA), neuropharmacology and metabolic disease (BG); drug discovery and chemistry (FB) and the biology of autophagy (EM). By synthesising their expertise and insights across these different domains, this cluster aims to advance our understanding of the complex interplay between ageing and neurodegeneration, paving the way for innovative strategies aimed at mitigating the impact of age-related brain disorders on human health and well-being.

Please see projects below

  1. Investigation of the interplay between circadian/sleep disruptions and Parkinson’s Disease

    Circadian rhythms and sleep are two processes perturbed in patients affected by neurodegenerative diseases such as Parkinson’s Disease (PD). PD patients manifest fragmented sleep, sleep-wake cycle disturbances and changes in cellular pathways controlled by circadian clocks. While it is accepted that these wake-sleep alterations are a consequence of PD progression, it is not fully understood whether circadian and sleep disruptions are risk factors for PD onset and progression. To answer this central question, the fruit fly Drosophila melanogaster will be used as model organism thanks to the high level of circadian and sleep mechanism similarities with humans. Using novel and cutting-edge genetic and molecular approaches in combination with established biochemical and behavioural assays, this project will provide new insights into whether disruption of the circadian clock and sleep plays a role in PD pathogenesis which ultimately will inform on therapeutic interventions to prevent Parkinson’s Disease and other neurodegenerative pathologies.

    Potential applicants can contact Carlo Breda, for any questions about the project or for informal enquiries.

  2. The glucosylceramide-depletion hypothesis for neurodegenerative disease: Role of lysosomal cations and membrane contact sites

    We have preliminary evidence that neurodegenerative diseases have a deficit in a particular type of biological molecule, a glucolipid. We have previously shown that glucolipid outside the lysosome leads to defective recycling inside lysosomes. The project will address a new hypothesis for how the lysosomes and mitochondria are not functioning correctly. We have identified new targets that increase glucolipids and help the lysosome work better in neurodegenerative disease. Using both external and internal collaborators the proposed studentship would use fly and cell culture models of disease to investigate the role of membrane contact sites in lysosomal cation gradients (Emily Eden UCL). Using fluorescent activity-based probes (Hans Aerts, Leiden) the localisation of GBAs in healthy and diseased cells as well as the effect of GBA inhibition on glycolipid levels and saturation using in house LC-MS.

    Potential applicants can contact Dr Dan Sillence, for any questions about the project or for informal enquiries.

  3. Analysis of the signalling pathways determining cellular fate (survival/death) in Parkinson’s Disease models

    Activation of the stress response signalling and mitochondrial dysfunction are two well-established features of Parkinson’s Disease. Previous research from our group evaluated the possible neuroprotective effect of the pharmacological activation of the mitochondrial quality control system in a cellular model of Parkinson’s Disease (PD). These studies showed that low-level activation of this system appears to be neuroprotective whereas a higher activation seems to induce pro-death stress signalling. RNA sequencing analysis provided a list of candidate genes relevant in these signalling cascades.

    This project aims to validate identified candidates and study their role in the context of PD. For that purpose, different cellular PD models will be used (genetic models, alpha-synuclein preformed fibrils model) and a range of cutting-edge techniques will be applied, such as quantitative real time PCR, epistasis analysis and the Cell Painting assay, that will provide valuable insights in terms of the phenotypic consequences of the varied manipulations performed.

    Potential applicants can contact Dr Marta Domínguez-Prieto, for any questions about the project or for informal enquiries.

  4. Chronic psychosocial stress as a risk factor for developing Parkinson’s disease

    Parkinson’s disease (PD) is the fastest growing neurological disorder globally. However, it remains incurable due to our lack of understanding of its aetiology and pathophysiology. Studies have shown that 90-95% of PD cases do not have a genetic cause and may develop due to environmental factors such as exposure to chronic psychosocial stress. Exposure to chronic stress has been shown to damage cells by inducing mitochondrial dysfunction, oxidative stress and inflammation. Interestingly all these processed have also been implicated in the pathogenesis of PD. Furthermore, several recent observational studies have shown that individuals with high-stress level jobs and post-traumatic stress syndrome are at a higher risk of developing PD. Despite such strong evidence linking stress to PD, whether chronic stress does lead to development of PD later in life and if so, the mechanisms through which this happens remains unknown.

    This project directly addresses these questions through employment of a range of cutting-edge research techniques including histology, pharmacology, molecular biology and behavioural assays, with the overall aim of providing invaluable insight into pathogenesis of PD and its prevention.

    Potential applicants can contact Dr Mohsen Seifi, for any questions about the project or for informal enquiries.

  5. Dissecting mechanisms of microbiome-brain interactions in brain ageing and age-related neurodegeneration

    Age-related neurodegenerative diseases including Parkinson’s disease (PD) are increasingly evidenced as multifactorial, multisystem conditions where the central nervous system works in communication with endocrine, metabolic and immune signalling pathways. Development of models that support integration of these multifactorial contributions are needed to obtain new insights into the disease etiopathology of age-related neurodegeneration and identify novel therapeutic approaches.

    There is evidence that the microbiome of PD patients may be different from healthy individuals, and modulation of the microbiome through various approaches, including administration of probiotics, is seen as a potential new therapeutic option. We have found that administration of aerobic bacteria to Drosophila models of PD leads to different viability and motor behaviour outcomes depending on the type of bacteria administered. Here we aim to combine the use of Drosophila model organisms of ageing and age-related neurodegenerative diseases with human cell co-culture models to identify physiological and behavioural changes, and dissect the cellular and molecular mechanisms involved in the microbiome-gut-brain interactions in PD. By employing a multidisciplinary approach, we shall define distinct pathways that modulate microbiome-gut-brain interactions that may be beneficial for PD treatment. This will allow us to inform, in more detail, the potential of current microbiome modulation therapies and how they may support increased health-span and healthy ageing.

    Potential applicants can contact Dr. Nicoleta Moisoi, for any questions about the project or for informal enquiries.

  6. How do the properties of fluorophores depend on their molecular structure?

    We lack a fundamental understanding of how molecular structure relates to the properties of fluorescent molecules, including how fluorescence varies with pH. This makes it hard to design fluorescent probes for use in environments, like the lysosomal lumen, where pH is not constant. This project will prepare a matrix of fluorophores from a number of different families and investigate how their fluorescence varies with parameters such as solvent, pH, temperature and viscosity. This systematic study will help progress our understanding of fluorophore chemistry from the current trial-and-error to molecular engineering. The discoveries will be applied to the development of fluorescent probes for lysosomal K+ and Ca2+ - these ion populations have been implicated in various disease states including neurodegeneration.

    Potential applicants can contact Dr Simon Wheeler, for any questions about the project or for informal enquiries.

 

How to apply

This is a two-stage application process.

Stage one

 Please send the following documents to PGRscholarships@dmu.ac.uk:

Deadline: Monday, 8 July 2024

Stage two 

Shortlisted candidates will be contacted to undergo an interview, and successful candidates will be contacted by Friday 26 July 2024 with a request to submit a full application through the DMU PGR Application Portal.

Deadline for full application: Friday 2 August 2024.

The successful candidate will commence their studies on the 1 October 2024.


PhD Studentship: Development of broad-spectrum host-targeting antivirals against coronaviruses

Project description

The current COVID-19 pandemic has highlighted the need for broad-spectrum antivirals, which can be deployed rapidly against coronaviruses and future emerging viruses. In this project, the successful candidate will work within a multidisciplinary team to identify and develop antiviral compounds against coronaviruses.

Viruses manipulate host pathways upon infection, activating cellular signalling pathways leading to changes in host cell protein phosphorylation. Kinases that regulate these pathways have been suggested to be important antiviral drug targets.

We have identified several kinase-targeting proteolysis targeting chimera (PROTAC) molecules that have anti-coronavirus activity. This project aims to take this further, to develop these PROTACs as pan-coronavirus inhibitors and investigate their mechanism of action using a combination of molecular biology and cell biology techniques.

This project provides a unique opportunity to work at the forefront of virology research, making important contributions towards understanding the fundamental aspects of coronaviruses, as well as having a positive impact on public health measures for infection control.

The successful candidate will based within the Leicester Institute of Pharmaceutical Innovation in the Leicester School of Pharmacy, with dedicated state-of-the-art facilities for undertaking the project.

The candidate will be supervised by Dr Maitreyi Shivkumar, and co-supervised by Dr Tim Snape, as part of an multidisciplinary research team, who will provide excellent training and support in scientific, technical, and transferable skills required to develop as a research scientist. Potential applicants can contact Dr Shivkumar or Dr Snape for any informal queries.

Techniques associated with the project

Cell and virus culture, molecular cloning, immunofluorescence and confocal microscopy, Western blotting, virus entry assays, drug inhibition assays, flow cytometry, transmission electron microscopy, NMR, medicinal chemistry.

Funding

DMU is offering a fully-funded 3-year PhD scholarship for this work, commencing on 1st January 2025. Tuition fees at Home level will be waived (international students will need to pay the difference between Home and International fees which is around £10k per year). The studentship comes with a stipend pegged at the UKRI rate, currently at £19,237 per annum.

Eligibility

Applicants must:

  • Possess a UK Honours degree in Biochemistry, Biomedical Sciences or related fields with at least an upper second class (or overseas equivalent), a Masters Degree in similar fields, or an academic or professional qualification plus experience in their sector or industry.
  • Be enthusiastic about the research topic.
  • Demonstrate the ability to clearly communicate complex ideas to a variety of audiences.
  • Be self-motivated and able to work independently and with a team.
  • Demonstrate competence in the use of the English language. Please see section 5b here for further details on meeting our English language entry criteria.

 

How to apply

This is a two-stage application process.

Stage 1: Please send the following documents to PGRscholarships@dmu.ac.uk:

Deadline: Friday 26 July 2024

Stage 2: Shortlisted candidates will be contacted to undergo an interview, and successful candidates will be contacted by Friday 9 August 2024 with a request to submit a full application through the DMU PGR Application Portal.

Deadline for full application: Friday 16 August 2024.

Scholarship letter will be issued by Friday 23 August 2024.


Midlands4Cities

The AHRC-funded Midlands4Cities Doctoral Training Partnership (M4C) brings together eight leading universities across the Midlands to support the professional and personal development of the next generation of arts and humanities doctoral researchers. M4C is a collaboration between the University of Birmingham, Birmingham City University, University of Warwick, Coventry University, University of Leicester, De Montfort University, Nottingham Trent University and The University of Nottingham.

Offering you cross-institutional supervision, training, mentoring and career support to ensure that you produce world-leading research and maximise your career potential. The Doctoral Training Partnerships awards IRO 80 PhD Arts and Humanities Research Council (AHRC) studentships applicants each year.

Through the partnership we aim to deliver excellence in all aspects of research supervision and training. We will assist you in acquiring the best supervision for your field of research, you will have access to a wide range of facilities and support networks across our campuses.

See further information on the application process.


 

Alumni discounts

De Montfort University offers alumni discounts for students that have previously studied with us at undergraduate or taught masters degree level. This discount is available to Home and International Students. This discount is only available to new starters and will be automatically applied if you are eligible.

Home alumni discount is £500 per year (full-time equivalent).

International alumni discount is £2,000 per year (full-time equivalent).


 

Additional funding opportunities

Schlumberger Foundation Faculty for the Future Fellowship 

Commonwealth Scholarships 

Amelia Earhart Fellowship 

Education Loans | Leicestershire | The Sir Thomas White Loan Charity

The Harry James Riddleston Charity